neurobiology of aging journal

• Behavioural Phenotyping of Transgenic Mice

This paper reviews the current work on mouse genetics, brain, and behaviour in my laboratory. It starts with an historical account of our research and shows how certain research themes, such as olfaction, learning, social behaviour, and environmental effects in rodents have led to our current research on behavioural phenotyping of inbred, mutant, knockout, and transgenic mice. We are concerned with finding neural and behavioural sequelae to genetic manipulations in mice and use a battery of tests to detect behaviours that are altered in genetically modified mice. In this way we are working to dissociate neural and behavioural effects of different gene manipulations in mouse models of neurodegenerative diseases. Sensory, motor, cognitive, affective, and social behaviours may all be affec...

..., and Theo Hagg in Anatomy and Neurobiology at Dalhousie, we correlated neural and behavioural... examined changes in visual ability with aging in mice with normal vision (C57BL/6J) and mice wit...

• Canadian Journal of Experimental Psychology
• Vol. 61 Nbr. 4, December 2007